Centre National Chalbi Belkahia de Pharmacovigilance (CNPV)

(+216) 71 260 691| pharmacovigilance@rns.tn|

Travaux scientifiques

Publications

Early interaction between tacrolimus and rifampin.
Charfi R, Ben Sassi M, Gaïes E, Bacha M, Jebabli N, El Jebari H, Daghfous R, Ben Abdallah T, Trabelsi S.
Tunis Med. 2019 May;97(5):722-725.

Therapeutic durg monitoring of cyclosporin using area under the curve in nephrotic syndrome.
Gaies E, Ben Sassi M, Charfi R, Salouage I, Jebabli N, ElJebari H, Klouz A, Daghfous R, Trabelsi S.
Tunis Med. 2019 Feb;97(2):360-364.

Comparison of two kits of anti-infliximab antibodies plasmatic measurement.
Charfi R, Mahmoud I, Ben Salem F, Moalla M, Bouden S, Sfar I, Saïdane O, Klouz A, Daghfous R, Gorgi Y, Abdelmoula L, Trabelsi S.
Ann Biol Clin (Paris). 2019 Aug 1;77(4):453-458. doi: 10.1684/abc.2019.1454.

Community-acquired pseudomembranous colitis precipitated by loperamide.
Aouinti I, Kaabi W, Charfi O, Lakhoua G, Hamza I, Daghfous R, El Aidli S, Kastalli S, Zaiem A.
Therapie. 2019 Sep;74(4):499-502. doi: 10.1016/j.therap.2019.02.003. Epub 2019 Feb 28.

Drug reaction with eosinophilia and systemic symptoms in pediatric patients: A clinicopathological study of 16 cases in the National Center of Pharmacovigilance of Tunisia.
Kaabi W, Zaiem A, Aouinti I, Charfi O, Kastalli S, El Aidli S, Daghfous R, Lakhoua G.
Therapie. 2019 Oct;74(5):531-535. doi: 10.1016/j.therap.2019.03.007. Epub 2019 Apr 4.

A persistent dyspnea induced by hydrochlorothiazide.
Kaabi W, Aouinti I, Charfi O, Zaiem A, Lakhoua G, Hamza I, Daghfous R, Kastalli S, El Aidli S.
Therapie. 2019 Sep;74(4):498-499. doi: 10.1016/j.therap.2019.03.009. Epub 2019 Apr 4.

Recurrence of DRESS syndrome to escitalopram or neosensitization?
Charfi O, Lakhoua G, Aouinti I, Kastalli S, Daghfous R, El Aidli S, Zaiem A.
Therapie. 2019 Sep;74(4):504-506. doi: 10.1016/j.therap.2019.02.005. Epub 2019 Mar 5.

Interferon β-induced acute pancreatitis: About two cases with literature review.
Aouinti I, Hamza I, Charfi O, Lakhoua G, El Aidli S, Daghfous R, Zaiem A, Kastalli S.
Therapie. 2019 Jun;74(3):449-450. doi: 10.1016/j.therap.2018.12.006. Epub 2019 Jan 2

Therapeutic monitoring of antiepileptic drugs in comatose patients.
Charfi R, Mizouri R, Ben Sassi M, Eljebari H, Jebabli N, Ben Salem F, Zerei S, Mrabet A, Daghfous R, Klouz A, Salouage I, Gaies E, Trabelsi S.
Tunis Med. 2018 Feb;96(2):129-134.

The HLA-B*15:02 polymorphism and Tegretol®-induced serious cutaneous reactions in epilepsy: An updated systematic review and meta-analysis.
Chouchi M, Kaabachi W, Tizaoui K, Daghfous R, Aidli SE, Hila L.
Rev Neurol (Paris). 2018 May;174(5):278-291. doi: 10.1016/j.neurol.2017.11.006.

Antiepileptic drugs administration by nasogastric tube in comatose patients
Charfi R, Mizouri R, Sassi MB, Gaies E, Eljebari H, Jebabli N, Zereï S, Salem FB, Said DB, Klouz A, Daghfous R, Salouage I, Trabelsi S.
Therapie. 2018 May - Jun;73(3):223-230. doi: 10.1016/j.therap.2017.08.002. Epub 2017 Oct 12. French.

Acute generalized exanthematic pustulosis induced by spiramycin : usefulness of patch testing.
Kastalli S, Charfi O, El Aïdli S, Zaïem A, Daghfous R.
Tunis Med. 2016 Jul;94(7):339.

Multiple drug intolerance syndrome in an epileptic woman.
Charfi O, Lakhoua G, Sahnoun R, El Aidli S, Daghfous R, Kastalli S, Zaïem A.
Therapie. 2016 Oct 19. pii: S0040-5957(16)30052-X. doi: 10.2515/therapie/2015052.

Fatal Kounis syndrome with stent thrombosis secondary to amoxicillin/clavulanic acid use: A case report and literature review.
Salouage I, El Aidli S, Kastalli S, Daghfous R, Lakhal M.
Therapie. 2016 Dec;71(6):535-539. doi: 10.1016/j.therap.2016.06.004. Epub 2016 Jul 21.

Intolerance to non-steroidal anti-inflammatory drugs.
Lakhoua G, Zaiem A, Sahnoun R, El Aidli S, Daghfous R, Kastalli S.
Therapie. 2016 Oct;71(5):525-528. doi: 10.1016/j.therap.2016.04.002. Epub 2016 Apr 26.

A hemophagocytosis syndrome attributed to phenobarbital.
Lakhoua G, Aouinti I, Sahnoun R, Kastalli S, Daghfous R, Zaïem A.
Presse Med. 2016 Mar;45(3):379-81. doi: 10.1016/j.lpm.2015.12.004. Epub 2016 Jan 29.

Multiple Drug Intolerance Syndrome in an Epileptic WomanSyndrome d'intolérance médicamenteuse multiple chez une femme épileptique.
Charfi O, Lakhoua G, Sahnoun R, El Aidli S, Daghfous R, Kastalli S, Zaïem A.
Therapie. 2015 Oct 26.

DRESS Syndrome Following Levofloxacin Exposure With Positive Patch-test.
Charfi O, Lakhoua G, Sahnoun R, Badri T, Daghfous R, El Aidli S, Kastalli S, Zaïem A.
Therapie. 2015 Nov-Dec;70(6):547-9. doi: 10.2515/therapie/2015046. Epub 2015 Aug 3. Review.

Bullous Eruption Associated With Dihydropyridines With Cross Reactivity.
Charfi O, Lakhoua G, Sahnoun R, Daghfous R, El Aidli S, Kastalli S, Zaïem A.
Therapie. 2015 Jul-Aug;70(4):381-3. doi: 10.2515/therapie/2015023. Epub 2015 May 8.

Genital fixed drug eruption induced by miconazole with positive provocation test.
Kastalli S, El Aïdli S, Lakhoua G, Daghfous R.
Tunis Med. 2014 Nov;92(11):703.

DRESS syndrome induced by ciprofloxacine
Sahnoun R, El Aïdli S, Zaïem A, Lakhoua G, Kastalli S, Daghfous R.
Nephrol Ther. 2015 Apr;11(2):111-3. doi: 10.1016/j.nephro.2014.11.004. Epub 2015 Feb 11. Review. French.

Probable disseminated BCG infection in a 10-month-old child after BCG vaccination.
Zaïem A, El Ferjani S, Lakhoua G, Sahnoun R, Badri T, Kastalli S, Daghfous R, Lakhal M, El Aidli S.
Hum Vaccin Immunother. 2014;10(7):2081-2. doi: 10.4161/hv.28913.

Facial hyperpigmentation during imatinib therapy for gastrointestinal stromal tumor.
Hamza I, Gaies E, Kastalli S, Daghfous R, El Aidli S.
Therapie. 2014 May-Jun;69(3):245-7. doi: 10.2515/therapie/2014018. Epub 2014 Jun 18.

Fixed pigmented erythema antihistamine H1: about 2 cases and review of the literature
Lakhoua G, El Aidli S, Zaïem A, Sahnoun R, Kastalli S, Hedi Loueslati M, Daghfous R.
Therapie. 2014 May-Jun;69(3):243-4. doi: 10.2515/therapie/2014001. Epub 2014 Jun 18. Review. French.

Lichen associated with metformin.
Zaïem A, Sahnoun R, Badri T, Lakhoua G, Koubaa W, Kastalli S, Daghfous R, Lakhal M, El Aidli S.
Therapie. 2014 May-Jun;69(3):253-4. doi: 10.2515/therapie/2014025. Epub 2014 Jun 16.

Anaphylactic shock induced by mephenesin.
Lakhoua-Ennaifer G, El Aidli S, Zaïem A, Chedly Z, Daghfous R, Lakhal M.
Presse Med. 2014 Oct;43(10 Pt 1):1134-5. doi: 10.1016/j.lpm.2014.01.017. Epub 2014 May 6.

Érythème pigmenté fixe aux antihistaminiques H1 : à propos de 2 cas et revue de la littérature.
Lakhoua G, El Aidli S, Zaïem A, Sahnoun R, Kastalli S, Loueslati MH, Daghfous R.
Therapie. 2014 May-Jun;69(3):243-4. doi: 10.2515/therapie/2014001. French.

Peripheral neuropathy during infliximab therapy for rheumatoid arthritis.
El Aidli S, Gaïes E, Cherif F, Zaiem A, Daghfous R, Lakhal M.
Presse Med. 2014 Sep;43(9):1012-4. doi: 10.1016/j.lpm.2013.12.011. Epub 2014 Apr 16.

Acute generalized exanthematous pustulosis with mephenesin balm.
Lakhoua G, El Aidli S, Zaïem A, Ben Mously R, Ben Brahim E, Daghfous R.
Presse Med. 2014 Jul-Aug;43(7-8):867-9. doi: 10.1016/j.lpm.2013.11.018. Epub 2014 Apr 2.

Meprobamate-induced fixed drug eruption.
Zaïem A, Kaabi W, Badri T, Lakhoua G, Sahnoun R, Kastalli S, Daghfous R, Lakhal M, El Aidli S.
Curr Drug Saf. 2014;9(2):161-2.

Clarithromycin induced psoriasis in a 37-year old man.
Zaiem A, Mebazaa A, Lakhoua G, Badri T, Sahnoun R, Kastalli S, Daghfous R, El Aidli S.
Curr Drug Saf. 2014 Mar;9(1):77-8.

Sulfasalazine-induced aseptic meningitis with positive rechallenge: a case report and review of the literature.
Salouage I, El Aïdli S, Cherif F, Kastalli S, Zaiem A, Daghfous R.
Therapie. 2013 Nov-Dec;68(6):423-6. doi: 10.2515/therapie/2013065. Epub 2013 Dec 20. Review.

Sulfasalazine-induced DRESS syndrome associated with Epstein Barr virus reactivation
Zaïem A, Aouinti I, Lakhoua G, Sahnoun R, Daghfous R, Lakhal M, El Aïdli S.
Therapie. 2013 Sep-Oct;68(5):321-3. doi: 10.2515/therapie/2013049. Epub 2013 Nov 14. French.

Imatinib plasma levels in the management of cutaneous side effects induced by imatinib (Glivec®): 2 case reports
Trabelsi S, Gaïes E, Sraïri S, Sahnoun R, Daghfous R, Lakhal M, El Aïdli S, Klouz A.
Ann Biol Clin (Paris). 2013 Mar-Apr;71(2):203-6. doi: 10.1684/abc.2013.0795. French.

Secondary nocturnal enuresis associated with valproic acid.
Zaïem A, Aouinti I, Lakhoua G, Kastalli S, Daghfous R, Lakhal M, El Aïdli S.
Therapie. 2013 Jan-Feb;68(1):59-60. doi: 10.2515/therapie/2013004. Epub 2013 Mar 14

Precocious puberty in an epileptic child treated with valproate.
Zaiem A, Aouinti I, Lakhoua G, Kastalli S, Daghfous R, Lakhal M, El Aïdli S.
Therapie. 2012 Nov-Dec;67(6):537-8. doi: 10.2515/therapie/2012071. Epub 2012 Dec 19.

Adverse drug reactions in older adults: a retrospective study from pharmacovigilance.
Charfi R, El Aïdli S, Zaïem A, Kastalli S, Sraïri S, Daghfous R, Lakhal M.
Therapie. 2012 Sep-Oct;67(5):471-6. doi: 10.2515/therapie/2012059. Epub 2012 Dec 18.

Serious adverse drug reactions in older adults notified to pharmacovigilance.
Charfi R, El Aïdli S, Zaïem A, Kastalli S, Sraïri S, Daghfous R, Lakhal M.
Therapie. 2012 Sep-Oct;67(5):465-70. doi: 10.2515/therapie/2012060. Epub 2012 Dec 18.

DRESS syndrome
Khaled A, Souissi A, Zeglaoui F, El Fekih N, Daghfous R, Fazaa B.
Tunis Med. 2012 Oct;90(10):749-51. French.

Teriparatide therapy for osteonecrosis of the jaw.
Chtioui H, Lamine F, Daghfous R.
N Engl J Med. 2011 Mar 17;364(11):1081-2; author reply 1082. doi: 10.1056/NEJMc1100730.

Cardiac arrhythmia induced by interferon beta-1a.
Kastalli S, El Aïdli S, Mourali S, Zaïem A, Daghfous R, Lakhal M.
Fundam Clin Pharmacol. 2012 Apr;26(2):207-9. doi: 10.1111/j.1472-8206.2010.00914.x. Epub 2011 Feb 24.

Bullous eruption in a patient treated with low dose of furosemide for lupic glomerulonephritis.
Mebazaa A, Zaïem A, Béji S, El Héni I, El Euch D, Mokni M, Ben Moussa F, Ben Osman A, Daghfous R, El Aïdli S.
Therapie. 2011 Mar-Apr;66(2):183-4.

Acute generalized exanthematous pustulosis. Study of 22 cases
Mebazaa A, Kort R, Zaiem A, Elleuch D, Moula H, Cheikhrouhou R, Trojjet S, Mokni M, Ben Osman A, Daghfous R.
Tunis Med. 2010 Dec;88(12):910-5. French

Drug induced colitis: review article
Gaïes E, Ouanes L, Trabelsi S, Salouage I, Klouz A, Daghfous R, Lakhal M.
Therapie. 2010 May-Jun;65(3):249-53. doi: 10.2515/therapie/2010014. Epub 2010 Aug 11. Review. French.

Photosensitivity induced by metformin: a report of 3 cases
Kastalli S, El Aïdli S, Chaabane A, Amrani R, Daghfous R, Belkahia C.
Tunis Med. 2009 Oct;87(10):703-5. French.

Eyelid necrosis after local anaesthesia for lacrimal sac surgery.
Mili-Boussen I, Errais K, Chebil A, Daghfous R, Belkahia C, Quertani A.
Eye (Lond). 2010 Jul;24(7):1296-7. doi: 10.1038/eye.2009.337. Epub 2010 Feb 5.

Fatal liver injury associated with clopidogrel.
Kastalli S, El Aïdli S, Zaïem A, ben Abdallah H, Daghfous R.
Fundam Clin Pharmacol. 2010 Aug;24(4):433-5. doi: 10.1111/j.1472-8206.2009.00791.x. Epub 2009 Nov 5.

Recurrent dysosmia induced by pyrazinamide.
El Aïdli S, Kastalli S, Zaïem A, Lakhoua G, Rejeibi I, Loueslati MH, Daghfous R, Belkahia C.
Fundam Clin Pharmacol. 2009 Oct;23(5):539-41. doi: 10.1111/j.1472-8206.2009.00736.x. Epub 2009 Aug 6.

Amoxicillin-induced phototoxicity
Kastalli S, Aïdli SE, Zaïem A, Lakhoua G, Daghfous R.
Ann Dermatol Venereol. 2009 Jun-Jul;136(6-7):540-1. doi: 10.1016/j.annder.2009.04.001. Epub 2009 May 15. French.

Drug Interaction between Sutent (sunitinib) and Bi-spirogyl (spiramycin-metronidazol): risk of toxicity
Trabelsi S, Boussen H, Gaïes E, Salouage I, El Aïdli S, Daghfous R, Loueslati MH, Lakhal M, Belkahia C.
Therapie. 2008 Nov-Dec;63(6):475-6. French.

Adverse events related to systemic treatment using Glucantime for cutaneous leishmaniasis: a report from Tunisia
Mlika BR, El Aïdli S, Ben Brahim M, Badri T, Chouk S, Ben Jannet S, Marrrak H, Daghfous R, Mokhtar I, Fenniche S.
Med Trop (Mars). 2008 Oct;68(5):499-501. French.

Interaction médicamenteuse entre Sutent® (sunitinib) et Bi-spirogyl® (spiramycine-métronidazole) : risque de toxicité: Drug Interaction between Sutent® (sunitinib) and Bi-spirogyl® (spiramycin-metronidazol) : Risk of Toxicity.
Trabelsi S, Boussen H, Gaïes E, Salouage I, Aïdli SE, Daghfous R, Loueslati MH, Lakhal M, Belkahia C.
Therapie. 2008 Nov-Dec;63(6):475-6. doi: 10.2515/therapie/2008068. French.

Leflunomide-induced toxic epidermal necrolysis
El Aïdli S, Salouage I, Kastalli S, Srairi S, Daghfous R, Loueslati MH, Belkahia C.
Therapie. 2008 Mar-Apr;63(2):157-8. French.

A case of anaphylactic reaction to ibuprofen in a child with Still's disease.
Bouyahia O, Nesserine N, Gharsallah L, Mazigh SM, Daghfous R, Boukthir S, El Gharbi AS
Therapie. 2008 Mar-Apr;63(2):155-6.

Systemic BCG reactions after intravesical BCG therapy. A report of four cases
Sfaxi M, Langar H, Ouni A, Riahi Y, El Aidli S, Daghfous R, Ben Abdeladhim A, Chébil M.
Therapie. 2008 Jan-Feb;63(1):43-7. doi: 10.2515/therapie:2008009. Epub 2008 Apr 4. French.

Réactions systémiques après traitement endovésical par le BCG : à propos de 4 cas.
Sfaxi M, Langar H, Ouni A, Riahi Y, Aidli SE, Daghfous R, Abdeladhim AB, Chébil M.
Therapie. 2008 Jan-Feb;63(1):43-7. doi: 10.2515/therapie:2008009. French.

Bullous erythema multiform induced by trihexyphenidyl
Trabelsi S, El Aïdli S, Kastalli S, Klouz A, Sraïri S, Lakhal M, Loueslati MH, Daghfous R, Belkahia C.
Therapie. 2006 Nov-Dec;61(6):537-9. French.

Anaphylactic Shock Induced by Injectable Form of Glucantime® following a Previous Sensitization by Cutaneous Way
Trabelsi S, Salouage I, Youssef S, Daghfous R, Loueslati MH, Lakhal M, Doss N, Belkahia C.
Therapie. 2007 Mar-Apr;62(2):185-6. doi: 10.2515/therapie:2007031. French.

Risk factors of side effects of antituberculosis drugs
El Gharbi L, Baccar MA, Azzabi S, Aouina H, Kallel H, Daghfous R, Bouacha H.
Tunis Med. 2006 Aug;84(8):487-91. French.

Nightmares induced by valsartan.
Kastalli S, El AS, Loueslati MH, Daghfous R, Belkahia C.
Therapie. 2006 Jan-Feb;61(1):81-2.

Serious bullous cutaneous lesions induced by isoniazid
Trabelsi S, El Aïdli S, Amrani R, Ourari B, Klouz A, Lakhal M, Loueslati MH, Daghfous R, Beji M, Belkahia C.
Therapie. 2005 Nov-Dec;60(6):599-600. French.

Allergic reactions to paracetamol
Daghfous R, El Aidli S, Jday A, Kastalli S, Klouz A, Srairi S, Lakhal M, Loueslati MH, Belkahia C.
Therapie. 2005 Sep-Oct;60(5):523-6. French.

Isoniazid acetylation in a group of Tunisian patients. Report of 620 patients
Mehiri BR, Zouaoui A, Chérif J, Ourari B, Daghfous R, Oueslati MH, Louzir B, Daghfous J, Chelbi B, Béji M.
Tunis Med. 2005 Jul;83(7):385-9. French.

Sildenafil-associated hepatotoxicity.
Daghfous R, El Aidli S, Zaiem A, Loueslati MH, Belkahia C.
Am J Gastroenterol. 2005 Aug;100(8):1895-6.

Drug tendon disorders
Daghfous R, El Aidli S, Gheni R, Belkahia C.
Tunis Med. 2005 May;83(5):253-7. Review. French.

Cholestasis soon after administration of amoxicillin-clavulanic acid
Daghfous R, El Aïdli S, Ben Mami N, Amrani R, Loueslati MH, Lakhal M, Belkahia C.
Therapie. 2004 Nov-Dec;59(6):658-60. French

Ofloxacin-induced achilles tendinitis in the absence of a predisposition
Aouam K, El Aïdli S, Daghfous R, Kastalli S, Lakhal M, Loueslati MH, Belkahia C.
Therapie. 2004 Nov-Dec;59(6):653-5. French.

Fixed drug eruption induced by sulfaguanidine
Kastalli S, El Aidli S, Daghfous R, Trabelsi S, Lakhal M, Loueslati MH, Belkahia C.
Ann Dermatol Venereol. 2004 Apr;131(4):382-4. French.

Nome gesrol (lutenyl) induced severe acute hepatitis.
Daghfous R, El Aidli S, Rjeibi I, Hédi Loueslati M, Lakhal M, Belkahia C.
Gastroenterol Clin Biol. 2004 Jan;28(1):94-5. French. 2004-01

Halothane-induced hepatitis. 8 case reports
Daghfous R, el Aïdli S, Sfaxi M, Daghfous M, Kastalli S, Sraïri S, Loueslati MH, Belkahia C.
Tunis Med. 2003 Nov;81(11):874-8. French. 2003-11

Are sigma receptors implicated in ischemic injury?
Klouz A, Loueslati MH, Daghfous R, Morin D.
Therapie. 2001 Sep-Oct;56(5):557-62. Review. French. 2001-09

Undesirable effects of antitubercular agents
Drira I, Jrad S, Ben Arif, Souissi R, Daghfous R, Bellkahia C, Chebbi ML.
Tunis Med. 76(2):1041-6. French. 1998-02

Alopecia caused by nimodipine
Daghfous R, Ben Amor S, Loueslati MH, El Aidli S, Srairi S, Lakhal M, Sebai S, Khaldi M, Belkahia C.
Therapie. 50(6):590-1. French. 1995-11

Inflammatory disease of the upper digestive tract probably due to a synthetic progestational agent
Daghfous R, Hedi Loueslati M, el Aidli S, Srairi S, Lakhal M, Belkahia C.
Gastroenterol Clin Biol. 19(10):853-4. French. 1995-10

The effect of drinking on the pharmacology of drugs
Daghfous R, Lakhal M, Loueslati MH, Belkahia C.
Tunis Med.73(2):105-8. Review. French. 1995-02

Management of undesirable side effects of medications
Daghfous R, Srairi S, el Aidli S, Belkahia C
Tunis Med. 72(10):581-3. French. 1994-10

Drug monitoring in Tunisia: organization and objectives
Daghfous R, Elaidi S, Loueslati MH, Srairi S, Lakhal M, Belkahia C
Tunis Med. 72(2):83-6. French 1994-02

Methyldopa-induced hepatitis: 3 case reports
Daghfous R, el Aidli S, Loueslati MH, Sakka T, Lakhal M, Ben Mami N, Ben Khelifa H, Belkahia CH
Tunis Med. 72(1):47-50. French 1994-01

Digitalis blood determination: why and when?
Daghfous R, Zghal K, Lakhal M, Loueslati MH, Belkahia C
Tunis Med. 71(4):183-6. Review. French 1993-04